In terms of messing up sounds, Reason gives you limitless possibilities. That's what it excels at, and that's why I love it. You can start with a basic four on the floor beat and turn it into something unrecognizable, ugly or brilliant.

The beauty of Reason is, that even if you have no experience in creating beats of your own, your able to dive right in using Dr Rex, and can be mangling things in no time at all!

Check out these videos from YouTube. Probably more suited for the beginner, but more experienced Reason users might find them interesting as well.

Part 1

Part 2

So, there you have it. Bang on.